Codylex Linctus: Very Effective to Treat Dry Cough Related with Respiratory Diseases
The Codylex Linctus is antitussive preparation, which contains codeine phosphate & chlorpheniramine maleate. It effectively treats painful and dry unproductive cough related with the respiratory diseases.
The Codylex Linctus is pointed for the symptomatic relief from coughs and associated upper respiratory symptoms related with infection, common cold, or allergy. It is very useful for the treatment of dry, unproductive, and hacking cough, which can be exhausting, hazardous, and sleep interfering.
For Adults: One teaspoonful or 5 ml in every 6 hours
For Children over 6 years): ½ teaspoonful or 2.5 ml in every 6 hours
For Children between 2 to 6 years: ¼ teaspoonful or 1.25 ml in every 6 hours
Codylex Linctus is usually not recommended for the Children below 2 years age.
Pharmacological properties of the given ingredients explain principles for their existence in the Codylex Linctus with their combined advantageous antitussive effects.
Codeine phosphate: It is the opioid derivative that has very good antitussive and analgesic property. Codeine phosphate is normally administered with mouth in form of Linctus to get relief from cough as it works selectively through suppressing the cough center in Central Nervous System. Codylex Linctus has cough suppressant effect, which is exerted via opioid receptors that actually increases threshold of cough center in brain for the incoming cough stimuli. Following the ingestion of the Codeine phosphate, the peak plasma concentrations reach in around one hour. The plasma half-life of Codeine is around 3 to 4 hrs. It is also metabolized in liver to norcodeine, morphine, and other metabolites. The source drug as well as its metabolites is eliminated mainly through kidneys like conjugates of the glucuronic acid.
Chlorpheniramine maleate: It is a reliable antihistamine, and plays a useful role in the cough suppression. Its anticholinergic as well as sedative actions are recommended to be liable for its advantageous effect for the cough treatment. It is having great value for treating cough originated by allergic rhinitis and post-nasal drip. Following the oral dosing, CPM (Chlor Pheniramine Maleate) is gradually absorbed from gastrointestinal tract with the bio-availability of around 25 to 50%. Its time period of action is around 4 to 5 hrs. It is around 70% protein bound with widely distributed in our body. The parent drug with its metabolites is ejected primarily in urine.
Codylex Linctus is usually risk-free and well-tolerated in the recommended doses. The episodic side effects determined with its utilization include drowsiness, anorexia, constipation, blurring of vision, nausea, dysuria, paradoxical stimulation of the CNS, and dryness of mouth. Codeine has very low abuse liability. With toxic doses, the Codeine causes profound drowsiness and respiratory depression. Patients using the Codylex Linctus are counseled to abstain from the alcohol ingestion as well as advised against doing hazardous activities like operating dangerous machines or driving. Codeine and other antihistamines are contraindicated with the patients, having asthmatics, diminished respiratory reserve, and the individuals, having history of any type of hypersensitive reaction from any of the elements of Codylex Linctus
Codylex Linctus is accessible in 50 ml as well as 100 ml bottles in menthol-based, raspberry flavored and sugar-free antitussive medicament.
Every 5ml Codylex Linctus contains:
Codeine phosphate IP 10 mg
Chlorphenamine Maleate IP 4 mg
Image Source: Morgue File dot com